Computational Biology and Bioinformatics

Volume 4, Issue 1, February 2016

  • A Comparative Analysis of Motif Discovery Algorithms

    Angela Makolo

    Issue: Volume 4, Issue 1, February 2016
    Pages: 1-9
    Received: Sep. 25, 2015
    Accepted: Oct. 26, 2015
    Published: Nov. 19, 2015
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    Abstract: One of the major challenges in bioinformatics is the development of efficient computational algorithms for biological sequence motif discovery. In the post-genomic era, the ability to predict the behavior, the function, or the structure of biological entities or motifs such as genes and proteins, as well as interactions among them, play a fundament... Show More
  • The Role of Calcium on the Active Site of Snake Venom Phospholipase A2: Molecular Dynamics Simulations

    Akubugwo Emmanuel I., Okafor Irene N., Ezebuo Fortunatus C., Lukong Colin B., Ifemeje Jonathan C., Nwaka Andrew C., Chilaka Ferdinand C.

    Issue: Volume 4, Issue 1, February 2016
    Pages: 10-14
    Received: Jan. 18, 2016
    Accepted: Jan. 28, 2016
    Published: Feb. 17, 2016
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    Abstract: Snake venoms are rich in phospholipase A2 (PLA2) and their hydrolysis of cell membrane phospholipids explains the role of the enzyme in venom toxicity. Calcium is known to plays important role at the active site of PLA2 during catalysis. In this study, molecular dynamics simulations of free PLA2 and calcium bound PLA2 were carried out using GROMACS... Show More