Computational Biology and Bioinformatics

Volume 8, Issue 1, June 2020

  • Comprehensive Phylogenetic Analysis of Root-knot Nematodes Predicts Emerging Virulent Species

    Kamrul Islam, Mohammad Jakir Hosen, Sourav Chakraborty, Auditi Purkaystha, Mahmudul Hasan, Bonhi Elora

    Issue: Volume 8, Issue 1, June 2020
    Pages: 1-8
    Received: Sep. 17, 2019
    Accepted: Dec. 30, 2019
    Published: Feb. 03, 2020
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    Abstract: Among the root-knot nematodes three Meloidogyne species namely Meloidogyne incognita, M. javanica, and M. arenaria are emerging as an important pest of many cultivated plants, and recognized as the most economically destructive plant parasitic nematodes species of all over the world. Although other root-knot nematodes may virulent for plant but lim... Show More
  • Discover the Dehydration Response Genes in Boea hygrometrica Transcriptome Using Bayesian Network Approach

    Mengmeng Zhang, Lu Wang, Ping Wan

    Issue: Volume 8, Issue 1, June 2020
    Pages: 9-14
    Received: Mar. 03, 2020
    Accepted: Mar. 18, 2020
    Published: Mar. 23, 2020
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    Abstract: “Drying without dying” is an amazing feature in land plant evolution. Boea hygrometrica is an important resurrection plant model. The current genome and transcriptome analysis have revealed that some biological processes may contribute to its dehydration tolerance, but genes play pivotal roles in the dehydration response remains unclear. Bayesian n... Show More
  • Discovering Escherichia coli K-12 Promoter Features Using Convolutional Neural Network

    Mengmeng Zhang, Lu Wang, Ping Wan

    Issue: Volume 8, Issue 1, June 2020
    Pages: 15-19
    Received: May 24, 2020
    Accepted: Jun. 08, 2020
    Published: Jun. 20, 2020
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    Abstract: The mechanism of prokaryotic gene expression remains incompletely understood. Promoters are regions in genome that locating upstream to genes and regulate of gene expressions. Despite more and more E. coli K-12 promoter sequences have been obtained experimentally, and some regions such as -10 region and -30 region have been described, the features ... Show More
  • The Effect of the Infection Rate on Oncolytic Virotherapy

    Dongwook Kim, Haeyoung Kim, Hui Wu, Dong-Hoon Shin

    Issue: Volume 8, Issue 1, June 2020
    Pages: 20-28
    Received: Jun. 10, 2020
    Accepted: Jun. 23, 2020
    Published: Jul. 04, 2020
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    Abstract: Oncolytic viruses have become a novel therapeutic tool for various cancer treatments. Several naturally occurring oncolytic viruses and engineered oncolytic viruses are developed for oncolytic virotherapies. Although we have a good understanding on molecular mechanisms of viral replication and virus-induced cell lysis at the cellular level, it is u... Show More